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The intercellular cement in the skin is primarily composed of?

  1. Water.

  2. Solvents.

  3. Lipids.

  4. Amino acids.

The correct answer is: Lipids.

The intercellular cement in the skin plays a crucial role in maintaining skin barrier function and integrity. It is primarily composed of lipids, which serve to hold skin cells together and help to prevent water loss while also protecting against environmental irritants and pathogens. These lipids, which include ceramides, cholesterol, and fatty acids, form a matrix that interlinks the corneocytes (the outermost skin cells) and is essential for a healthy, functioning skin barrier. Water is important for skin hydration, but it does not make up the structure of the intercellular cement itself. Solvents and amino acids, while they may play roles in skin biology and function, do not constitute the primary components of the intercellular cement. The focus on lipids reflects their vital function in skin health, particularly for moisture retention and barrier protection.